Biography
Shree Hegde completed her PhD at the University of Vienna, including a dissertation carried out at University of Veterinary Medicine. Her PhD research elucidated novel molecular and cellular mechanisms facilitating the successful infection of opportunistic ruminant pathogen mycoplasma agalctiae. Following this, she joined the University of Texas Medical Branch as a postdoctoral fellow to study the role of gut microbiota and bacterial infection during functional colon motility disorders.
In January 2021, Shree joined the Centre for Drugs and Diagnostics at the Liverpool School of Tropical Medicine to work towards developing new diagnostics tools and therapeutic treatments for human and zoonotic filarial infections.
Research interests
Shree’s wider research interest is in infection biology, particularly studying host-pathogen/parasite interaction. Currently she is working with experts in interdisciplinary areas and international partner organisations to develop novel and affordable anti-wolbachia curative treatment for filarial infections. She is part of a multi-disciplinary team developing an innovative non-invasive diagnostic tool for human lymphatic filariasis. Shree is also currently leading a research programme funded by UK Research and Innovation to investigate therapeutic potential of bioactive lipids in treatment of filarial immunopathologies
Teaching
Shree undertakes a supervisor role for MSc and MRes research projects and supports the a module covering lymphatic filariasis biology.
Selected research publications
Effects of Coffee on Gut Microbiota and Bowel Functions in Health and Diseases: A Literature Review – Journal: Nutrients – Published: 18th September 2024
Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts – Journal: Nature Microbiology – Published: 4th September 2024
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis – Journal: Frontiers in Microbiology – Published: 1st February 2024
Dirofilariasis mouse models for heartworm preclinical research – Journal: Frontiers in Microbiology – Published: 22nd June 2023
Mechanistic Study of Coffee Effects on Gut Microbiota and Motility in Rats – Journal: Nutrients – Published: 18th November 2022
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